MTOR and glioblastoma: It has also been shown to modulate key intracellular signaling pathways, such as phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK), in cell lines including glioblastoma U373, H7, and HAP1.