GH has been demonstrated to enhance the prognosis of IS through the regulation of apoptosis, inflammation, and the PI3K/AKT signaling pathway and to attenuate myocardial ischemia–reperfusion injury by activating GSTP and inhibiting the ASK1-JNK/p38 pathway [15,16,19,47]. The gene discussed is MAP3K5; the disease is myocardial ischemia.