Briefly, 12–15-week-old WT (n = 22), Gpr4−/− (n = 9), Ogr1−/− (n = 14), and Gpr4−/− × Ogr1−/− × (n = 4) littermate mice were exposed to DSS for 8 days, resulting in pronounced colitis. Here, GPR68 is linked to colitis.