Il10−/− (n = 17), Il10−/− × Gpr4−/− (n = 13), Il10−/− × Ogr1−/− (n = 10), and Il10−/− × Gpr4−/− × Ogr1−/− (n = 10) developed colitis after approximately 190 days. The gene discussed is GPR68; the disease is colitis.