High-grade and dedifferentiated CSs harbor additional oncogenic alterations common to many types of sarcomas, such as inactivation of CDKN2A/2B, TP53, and RB1, alterations of hedgehog pathways, alterations in genes related to telomere regulation such as TERT gene amplifications, TERT promoter mutations, and alpha thalassemia/mental retardation syndrome X-linked (ATRX) mutations [22,23]. Here, TERT is linked to sarcoma.