AKT1 and Cowden syndrome 1: Of note, a dual inhibitor of bromodomain-containing protein 4 (BRD4) and PI3K-Akt-mTOR, SF2523 blocked Akt-mTOR activation and downregulated MYC and Bcl2 expression in the CS cell line SW1353 and in vivo strongly impaired its subcutaneous tumor growth in immunodeficient mice [41].