Triggering of death receptor 5 (DR5), a proapoptotic multimeric cell surface receptor that is activated after binding tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), is a potent inducer of apoptosis in tumor cells but not in normal cells [91], and remarkable antitumor activity has been demonstrated also in CS. This evidence concerns the gene TNFRSF10B and neoplasm.