During the HF transition from anagen to catagen, the core DEP nodes in the skin also involve lipid metabolism-related proteins (Fasn, Acsl1, Plin2, and Decr1), fibronectin binding-related protein (Pxdn), and keratin (Krt85 and Krt80) (Figure 5B). This evidence concerns the gene PXDN and hydrops fetalis.