ACE and cardiovascular disorder: Ang 1–7, acting through the Mas receptor, as well as Ang II, acting through the Angiotensin II receptor type 2 (ATR2), antagonize the effects of the canonical angiotensin-converting enzyme (ACE)–Ang II–ATR1 axis, resulting in a beneficial effect for cardiovascular diseases by anti-inflammatory responses, vasodilation, anti-apoptosis, and anti-fibrosis [15,16,17,18].