Similar to the matched analysis, decreasing mean serum levels of Ang 1–7, Ang I, and aldosterone were observed in aneurysm patients treated with ACEi, and decreasing levels of Ang 1–5, Ang II, Ang III, and Ang IV were observed in aneurysm patients without ACEi after surgical or endovascular treatment. The gene discussed is ANGPT1; the disease is aneurysm.