UBE2I and placental insufficiency: Extrapolating the data of other authors to our study, the joint action of the increased levels of conjugated forms of SUMO 1 and UBC9 may be considered as a stimulating mechanism for the release of presynaptic proteins and neurotransmission, as well as for modification of the FNE proteome and neuroprotection under hypoxia/ischemia caused by placental insufficiency.