Human HRG is a multi-domain plasma glycoprotein that interacts with Zn2+, pro-myosin, heparin, heparan sulfate, fibrinogen, and other ligands to exert various biological functions [20], including neutralizing the anticoagulant effect of heparin, binding divalent cations and heparin, removing immune complexes, and regulating tumor angiogenesis and immune responses [21,22]. This evidence concerns the gene HRG and neoplasm.