The results show that GJC aqueous extract exerts its anti-PF effects mainly by regulating expressions of metabolites (e.g., arachidonic acid, 5-HETE, 8-HETE) and key enzymes (e.g., ALOX5, PTGS2, PTGS1, CYP2C9, PLA2G2A) in the AA metabolic pathway. This evidence concerns the gene PTGS2 and pemphigus foliaceus.