In another study, a 5-week MIT program on db/db mice at a speed of 10–11 m/min was carried out, and it is found that exercise reduced the level of myocardial dynamin-related protein 1 (Drp1), which is a regulator of mitochondrial fission, along with the upregulation of mitochondrial transmembrane potential, thereby alleviating the excessive fission of cardiomyocytes mitochondria, improving mitochondrial function and preventing DCM-related cardiac remodeling [46]. The gene discussed is DNM1L; the disease is familial dilated cardiomyopathy.