Another meta-analysis of 2033 participants, among whom 7% had T2DM and 11% were overweight or obese, demonstrated that the high-intensity interval training (HIIT) group had better global insulin sensitivity than the continuous exercise group and the non-exercise group, thus reducing global insulin resistance (IR), which would improve the energy metabolism of cardiomyocytes to potentially function as an inhibitor of DCM [19]. This evidence concerns the gene INS and familial dilated cardiomyopathy.