FGFR1 and myocardial infarction: Based on this, another study in a mice model with myocardial infarction (MI) investigated that 6-week aerobic exercise (10 m/min, 55 min/day, 5 days/week) elevated the protein expression of FGF21 and FGFR1 in cardiomyocytes, as well as decreased oxidative stress and apoptosis.