IGF1 and familial dilated cardiomyopathy: However, compared to the non-exercise group, 5-week HIIT and moderate-intensity continuous training (MICT) significantly inhibited the expression of miR-1 in cardiac tissues and upregulated the mRNA expression of its downstream anti-apoptotic target insulin-like growth factor 1 (IGF-1) and its receptor IGF-1R, thereby inhibiting the apoptosis of cardiomyocytes and alleviating DCM, which indicates that the favorable impacts of exercise on DCM may be partly regulated by the downregulation of miR-1 expression [114].