TDG and familial dilated cardiomyopathy: In addition, α-KG also increased the binding of the TET to thymine DNA glycosylase (TDG) to form the TET1-TDG complex, thus promoting the oxidation of 5′ methylcytosine (5 mc) to cytosine in the diabetic heart, and thereby removing methylation and hydroxymethylation modifications in the left ventricular genome of DCM and restoring the cardiac function [89].