Compared to the control group, 4-week treadmill exercise significantly upregulated the expression of SIRT1 protein in the heart tissues of rats with DCM, and the results of PECAM1/CD31 immunofluorescence staining showed that the cardiac angiogenesis was increased, suggesting that exercise alleviated DCM at least partly through promoting angiogenesis via SIRT1. The gene discussed is SIRT1; the disease is familial dilated cardiomyopathy.