The primary causes of MD involve mutations in genes encoding key proteins, such as dystrophin and dystroglycan, which are essential for stabilizing the muscle membrane or glycosyltransferase-like protein O-mannosyltransferases (POMTs) and fukutin, which are crucial for dystroglycan glycosylation [12,13,14,15,16]. The gene discussed is DAG1; the disease is Menkes disease.