Our analysis of LCAT methylation level differences in different tumors found that compared to normal tissues, LCAT is hypermethylated in BRCA, COAD, HNSC, LUSC, PRAD, and UCEC and hypomethylated in KIRC, KIRP, and pancreatic adenocarcinoma (PAAD). The gene discussed is LCAT; the disease is pancreatic adenocarcinoma.