In order to examine the degree of conservation of CRG expression between primary tumor samples and metastases, we compared bulk RNA-seq from SKCM metastatic samples with 20 types of primary tumors (including primary SKCM), using CRG expression (z score values of RNA-seq by expectation maximization (RSEM) expression), from The Cancer Genome Atlas (TCGA) [33] (Figure 1A). The gene discussed is CHD7; the disease is neoplasm.