CD274 and neoplasm: Leyao et al. summarized the progress of the study of CSCs in radioresistance linked to the regulation of autophagy and immune network regulation and illustrated that radiation affects the infiltration of M2-type tumor-associated macrophages (TAMs), promoting EMT and facilitating the activation of PD-1/PD-L1, which reduces the T cell secretion, leading to immune evasion and promoting radioresistance [69].