PIAS3 and neoplasm: Interestingly, we noted that the expressions of PIAS3 (p = 0.0091) and SOCS3 (p < 0.05) were higher in tumors in comparison to mastopathy (tumor vs. mastopathy: PIAS3 2.79 ± 1.26 vs. 1.19 ± 0.51, p < 0.05; SOCS3 1.15 ± 0.64 vs. 0.78 ± 0.57, p < 0.05), and STAT5 was significantly lower in tumors in comparison to the tumor margin (tumor vs. normal: STAT5A 2.14 ± 1.86 vs. 52.24 ± 112.4, p < 0.001; STAT5B 0.8 ± 0.54 vs. 8.28 ± 10.47, p < 0.001).