Over this time, we observed an inverse trend, as shown in Figure 10A. Moreover, patients with a lack of PIAS3 in the nucleus were characterized by longer patient survival (mOS: not reached, HR = 3.41, 95% CI 0.86–13.6) (Table 1A), as shown in Figure 10B. Kaplan–Meier plots based on mRNA showed that a higher level of PIAS3 mRNA was related to a shorter OS survival of BC patients (mOS: not reached, HR = 1.58, 95% CI 1.03–2.42, p = 0.035) (Figure 10C). This evidence concerns the gene PIAS3 and breast cancer.