However, the PIAS3 (nuclear) level significantly increased with tumor histology grade (G1: 0.26 ± 0.44, G2: 0.45 ± 0.49, G3: 0.68 ± 0.46, p < 0.001; G1 vs. G2: p < 0.01, G1 vs. G3: p < 0.001, G2 vs. G3: p < 0.001) (Figure 3B). Here, PIAS3 is linked to neoplasm.