Moreover, it was reported that under the catalysis of polycomb reactive complex 2 (PRC2), EZH2 can inhibit the transcription of its target gene through the trimethylation of Lys-27 on histone 3 (H3K27me3), thus controlling the expression of FOXC1 in breast cancer [37,127,128]. Here, FOXC1 is linked to breast carcinoma.