PPARG and obesity due to melanocortin 4 receptor deficiency: In addition, we further demonstrated that microvesicle-shuttled miR-130b reduced fat deposition in recipient primary cultured porcine adipocytes by inhibiting PPARG expression, and intravenous injection of microvesicle-delivery miR-130b alleviated high-fat diet (HFD)-induced obesity in C57BL/6 mice through translational repression of Pparg [15].