BRCA1 and breast carcinoma: HRD in breast cancer is associated with germline and somatic mutations in BRCA1/2 tumor suppressor genes, BRCA1 promoter methylation, or mutations in other genes involved in homologous recombination such as RAD51C, RAD51D, PALB2, BRIP2, BARD1, ATM, and CHEK2 [138,141,142,143].