A recent study found that high PD-L1 expression in carcinomas lacking the SWI/SNF-related matrix-associated tumor suppressor gene which acts as an independent regulator of chromatin subfamily B member 1 (also known as INI-1 or BAF47, located on chromosome 22q11.2) was associated with favorable immune checkpoint inhibitor response, even in cases with low TMB. The gene discussed is CD274; the disease is carcinoma.