In this pathway, under the constant hyperglycemia, the synthesis of diacylglycerol (the endogenous activator of PKC) is elevated and leads to the activation of the isoforms of protein kinase-C, -β, -δ, and -α and p38 mitogen-activated protein kinase, causing important structural and functional abnormalities [48,51]. This evidence concerns the gene PRRT2 and Hyperglycemia.