When patients were divided into three PSA subgroups (PSA ≤ 10, 10 < PSA ≤ 20, 20 < PSA < 50), a significant increasing trend in PCa detection rate was noticed over time in all subgroups (all p < 0.05, Figure 1C, R2 range: 0.517–0.854). The gene discussed is KLK3; the disease is posterior cortical atrophy.