The rs11556218 (T>G) missense mutation in exon 6 is linked to higher IL-16 levels in TG/GG genotypes [51,52], with the G allele increasing the risk of lung [53], oral [54], nasopharyngeal [52], gastric [50,55,56], and colorectal cancer [55], as well as osteosarcoma [51], endometriosis [57,58], cardiovascular disease [50], and SLE [59]. The gene discussed is IL16; the disease is systemic lupus erythematosus.