IL16 and systemic lupus erythematosus: IL-16 is linked to inflammatory and autoimmune diseases, such as asthma, multiple sclerosis, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA) [42,46,47,48], as well as inflammation-driven conditions like susceptibility to viral infections, depression, and cardiovascular diseases [42,49,50].