FMR1 and autism: When each of the covariates was entered into the HLM, main effects were noted for Autism status, F (1, 40) = 4.29, p < 0.04, and Leiter-R Age Equivalent, F (1, 96) = 8.28, p < 0.005, but these main effects were minimized by the presence of a two-way interaction between Leiter-R and FMRP, F (1, 96) = 6.27, p < 0.01, as well a three-way interaction between Leiter-R, FMRP, and Autism status, F (1, 96) = 7.01, p < 0.009 (see Table 3).