Eligibility required positive allergy testing and IgE levels of 30–1300 IU/mL (for children aged 6–11 years in the United States), 30–700 IU/mL (for individuals aged ≥ 12 years in the United States), or 30–1500 IU/mL (in the European Union) [52]. Here, IGHE is linked to allergic disease.