The third one covered genes associated with bone, skin, and cartilage tissue development or diseases related to these tissues (ASPN, OMD, OGN, EPB41L4A, ADAMTS8, ADAMTS2, RIN3, IQCF3, RCBTB1, ABHD5) [45,60,63,64,65,66,67,68,69]. The gene discussed is ADAMTS8; the disease is occult macular dystrophy.