Others have reported that IL6 promoted the interaction of the TNIK/β-catenin/TCF4 complex (multiple myeloma cells: [78]); transcriptional activity of the β-catenin/TCF4 complex is promoted by TNIK [79] and inhibited by SF1, which induces an alternative splicing activity [80]. The gene discussed is TCF4; the disease is plasma cell myeloma.