Patients with a history of severe COVID-19 (vascular, pulmonary, or neurological manifestations) and those with post-COVID syndrome should be tested once for aCL IgG/IgM, anti-β2GPI IgG/IgM, and lupus anticoagulant [LA], and retested after three months if at least one of the aPLs was positive. The gene discussed is APOH; the disease is COVID-19.