APOH and autoimmune polyendocrinopathy: In addition to clinical criteria for thrombosis or pregnancy complications, for the diagnosis of APS, the detection of at least one of the APLs (lupus anticoagulant (LAC), anticardiolipin (aCL) antibodies or anti–beta2glycoprotein I (anti-β2GPI) antibodies of the IgG/IgM class) is mandatory, which must be confirmed as persistent at least twice, at least 12 weeks apart [18].