The search for local biomarkers that can better characterize the spectrum of severity of CRSwNP compared to B-EOS is still ongoing, and a few have been suggested (i.e., Calprotectin and IL-5); therefore, the negative correlation (r), although not significant, among B-EOS and symptoms [22] is not surprising. Here, IL5 is linked to chronic rhinosinusitis with nasal polyps.