For sPD-L1, a statistically significant increase in median concentrations was observed with advanced tumor size (T3–T4 vs. T1–T2, p = 0.0003), higher disease stage (III–IV vs. I–II, p = 0.0011), and the presence of regional metastases (N+ vs. N0, p = 0.014). This evidence concerns the gene SPDL1 and neoplasm.