By cross-referencing the 1368 differentially expressed genes obtained from a public database within the training set with the 157 genes identified through MR analysis, we found that seven genes—ZNF544, ZNF626, SLK, HIGD2A, RFWD3, C5, and SECTM1—were significantly associated with endometrial cancer. This evidence concerns the gene HIGD2A and endometrial cancer.