For example, factors like tumor necrosis factor (TNF-α) and interleukin 1 beta (IL1B) not only promote the recruitment and activation of inflammatory cells but may also trigger immune responses in distant tissues, potentially underlying the connection between periodontal disease and systemic illnesses like cardiovascular diseases [4], diabetes [5], and other diseases related to systemic immunity [6]. The gene discussed is IL1B; the disease is diabetes mellitus.