Marioni et al. explored circulating inflammatory markers (C-reactive protein (CRP), Interleukin-6 (IL-6), and Tumor Necrosis Factor-alpha (TNF-α)) in 1066 patients with T2DM and found that higher IL-6 and TNF-α levels were associated with worse cognitive scores after adjustment for sex and age [86]. This evidence concerns the gene TNF and type 2 diabetes mellitus.