IL6 and hydrops fetalis: Inflammaging involves chronic innate immune activation, leading to the release of inflammatory cytokines as Interleukin-1 (IL-1), TNF-α, and IL-6 that exacerbate HF mechanisms like Nuclear factor kappa B (NF-κB) activation and NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome formation drive systemic inflammation, oxidative stress, arterial stiffness, and endothelial dysfunction, increasing cardiovascular risk [24].