RUNX2 and neoplasm: The regulation of bone mass and homeostasis depends on the presence of adipogenic (e.g., c-receptor activated peroxisome proliferator (PAPARg)) or osteogenic factors ((e.g., runt-related transcription factor 2 (Runx2) and core-binding factor alpha 1 (Cbfa1)) that may be present in the bone microenvironment; the behavior of tumor cells has been shown to be influenced by the presence of adipocytes and adipocyte-associated factors.