The lymphatic endothelial cells (LECs), a component of LVs within the pre-metastatic niche, can be conditioned by tumor-secreted IL-6 to express CCL5 and VEGF, which facilitate C-C chemokine receptor type 5-positive (CCR5+) tumor cell recruitment, extravasation and colonization into the niche [138]. The gene discussed is IL6; the disease is neoplasm.