Plant-based medicines exert gastroprotective properties via mitigation of heartburn through inhibition of H+/K+-ATPase, alteration of GHR (ghrelin) sensitivity (which decreases hunger), increase in CCK and GLP-1 release, fasting leptin levels, gastric motility, suppression of abdominal pain causing L-type calcium channels, impediment of 5-HT3 receptors that lead to symptoms of dyspepsia, inhibition of α2-adrenergic receptors, and regulation of mucus production [142]. This evidence concerns the gene GHRL and dyspepsia.