Nine of the above top ten enriched pathways were involved, including MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, proteoglycans in cancer, Wnt signaling pathway, signaling pathways regulating pluripotency of stem cells, breast cancer, FoxO signaling pathway, growth hormone synthesis, secretion and action. The gene discussed is GH1; the disease is breast carcinoma.