Twelve genes have been reported as potential regulators of HT in ischemic stroke in previous studies: Casp3, Csf2, Ctnnb1, Cxcl12, Hif1a, Il1b, Mtor, Ptgs2, Ptprc, Tlr2, Tlr4, and Vcam1 [41,42,49,50,51,52,53,54,55,56,57,58]. This evidence concerns the gene TLR4 and ischemic stroke.