The upregulation of G077640, an uncharacterized hypoxia-responsive lncRNA, promotes ESCC proliferation and migration involved in tumorigenesis by interacting with histone H2AX and HIF-1α, which altered hypoxia-related glycolysis, including PDK1, HK2, and GLUT4, but G077640 knockdown attenuates ESCC progression [35]. The gene discussed is HK2; the disease is esophageal squamous cell carcinoma.