Patients with ESCC with poor survival and advanced stages had higher PFKL expression levels, but the antipsychotic drug, penfluridol, significantly attenuated ESCC by suppressing PFKL to activate AMP-activated protein kinase (AMPK), forkhead box-containing protein 3a (FOXO3a), and Bcl-2-interacting mediator of cell death (BIM) signaling for glycolysis inhibition and apoptosis induction [22]. This evidence concerns the gene FOXO3 and esophageal squamous cell carcinoma.