NOTCH1 and cancer: CTNNB1 and FBXW7 genes are some of the most altered Wnt pathway genes in OC [9], while in the Notch pathway the receptors (NOTCH1-4), ligands (such as DLL1, JAG2), as well as the canonical target (HES1), are some of the most dysregulated Notch genes in cancers overall [11].