TCGA comparison to GTEx normal tissue gene expression of Notch pathway genes showed an AUC of NOCTH1 (0.603), NOTCH2 (0.532), NOTCH3 (0.739), NOTCH4 (0.948), HES1 (0.642), DLL1 (0.823), JAG2 (0.769) [27], while in comparison our smaller study showed slightly higher AUC values of NOTCH1 (0.765), NOTCH2 (0.884), HES1 (0.950), DLL1 (0.907), and lower AUCs of NOCTH3 (0.714), NOTCH4 (0.907) and JAG2 (0.500) when comparing HGSOC and benign gynecologic tumors. The gene discussed is NOTCH2; the disease is benign female reproductive system neoplasm.