To evaluate the level of virulence in vivo of the ctpA deletion in Mtb, the survival, bacterial loads, and extension of tissue damage (percentage of lung area affected by pneumonia) were determined in BALB/c mice infected intratracheally with 2.40 × 105 CFU of MtbH37Rv or 2.07 × 105 CFU MtbH37RvΔctpA [43,48,59]. Here, EPHA2 is linked to susceptibility to pneumonia measurement.