In contrast, among our patient groups, we could not detect an association between VEGF and AGEs, but there was a correlation between VEGF and sRAGE, while AGE/sRAGE correlated negatively with VEGF in the neuropathy group before ALA, which seems to strengthen the hypothesis that among T2DM patients, sRAGE might be a risk factor of endothelial dysfunction and consequent vascular events. This evidence concerns the gene VEGFA and type 2 diabetes mellitus.