CASP3 and neuroblastoma: Similar to our findings, other studies also demonstrated reduced cell viability, mitochondrial dysfunction and activation of caspases 3 or 7 following treatment with Aβ42 oligomers in primary cortical [69] and hippocampal [70,71] neurons, HT-22 neuronal [72], SH-SY5Y [73,74], and LAN5 neuroblastoma cells in culture [43].