ZNF384, rearranged in 6% of childhood B-ALL cases, and ZNF362, often rearranged in ZNF384-like cases, encodes C2H2-type zinc-finger transcription factors and rearranges with genes encoding N-terminal transcription factors (e.g., TAF15 and TCF3) or chromatin modifiers (most commonly EP300, but also CREBBP, SMARCA2, and ARID1B) [98,99]. The gene discussed is TCF3; the disease is precursor B-cell acute lymphoblastic leukemia.