PAX5 and acute lymphoblastic leukemia: Two B-ALL subtypes are associated with PAX5 alterations with an intermediate to favorable prognosis, PAX5 p.Pro80Arg mutation (PAX5 P80R) [105] and PAX5-altered (PAX5alt), that includes rearrangements (commonly with ETV6 or NOL4L), mutations, or intragenic amplifications [13,103,104].