BCR-ABL1-like ALL involves different genetic alterations: ABL-class gene fusions (ABL1, ABL2, CSF1R, PDGFRB, and PDGFRA), found in about 10% of patients, and CRLF2 rearrangements present in more than 50% of Ph-like cases. Here, CRLF2 is linked to acute lymphoblastic leukemia.