CHRM2 and atrial fibrillation: Use of antipsychotics had a 17% increased risk of AF (adjusted OR: 1.17, 95% CI: 1.10–1.26). Risk of AF was increased in a dose-dependent way with antipsychotic usage (p < 0.001). Agents with higher muscarinic M2 receptor binding affinity showed a higher incidence of AF.