TRPV1 activation mediates the contribution of phosphorylated phosphoinositide 3-kinase (pPI3K), phosphorylated Akt (pAkt), and phosphorylated mammalian target of rapamycin (pmTOR) in pain modulation, indicating a crucial role in central sensitization associated with fibromyalgia pain in both the peripheral and central nervous systems [7,8,9,10]. Here, TRPV1 is linked to fibromyalgia.