AIM2 and prostate carcinoma: This led us to think that AIM2 overexpression was mainly observed during prostatic infection, but the activation of the Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) during hypoxic conditions, typical of prostate cancer, can increase AIM2 expression [74], a result confirmed by Qin et al. [30], who found that the AIM2 gene was expressed at high levels in prostatic adenocarcinoma with a dismal prognosis [30].