Based on this concept and according to the proved link between the PI3K/AKT/mTOR signaling pathway and the AIM2 inflammasome in certain types of cancers [24,49], Zheng et al. [58] evaluated the possible crosstalk between the mTOR pathway and AIM2 inflammasome in osteosarcoma establishment [58]. This evidence concerns the gene AKT1 and osteosarcoma.