AIM2 and acute pancreatitis: A previous study has already highlighted that circulating immune cells isolated by patients with acute pancreatitis were characterized by the increased expression and activation of AIM2 during the onset of the disease [85]; moreover, AIM2 levels and the AIM2-associated IL-1β release by peripheral blood mononuclear cells (PBMCs) were correlated to systemic inflammation in these patients [85].