The analysis of the bulk RNA sequencing (RNA-seq) database from lung adenocarcinoma (LUAD) patients demonstrated that, according to mRNA expression, AIM2-positive LUAD tissues were characterized by the increased recruitment of resting myeloid DCs (mDCs) and CD4-positive memory T cells that collaborated to create an immunosuppressive TME facilitating tumor growth at the basis of the dismal prognosis of patients [19]. This evidence concerns the gene AIM2 and neoplasm.