To note, a gene expression analysis in the public database of Skin Cutaneous Melanoma (SKCM) revealed that AIM2 was significantly down-expressed, that it had a high percentage of SNVs, and that its expression was negatively correlated with copy number variations (CNVs) [30], suggesting the anti-tumor role of AIM2 in melanoma. The gene discussed is AIM2; the disease is melanoma.