In accordance with the previous data about the pro-carcinogenic role of AIM2 in lung cancer, Zheng et al. [99] demonstrated that the upregulation of mRNA levels of AIM2 in tumor tissues was associated with the absence of Epidermal growth factor receptor (EGFR)/KRAS/anaplastic lymphoma kinase (ALK) mutations [99]. This evidence concerns the gene KRAS and neoplasm.