HMGB1 and pancreatic ductal adenocarcinoma: Li et al. [86], by taking advantage of pink1 knockout- and park2 knockout-mice found that mitochondrial iron-mediated oxidative DNA injury led to AIM2 inflammasome activation in pancreatic ductal adenocarcinoma (PDAC) cells, which in turn induces High Mobility Group Box 1 (HMGB1) release and the subsequent CD274 (encoding PD-L1) expression [86].