In human breast cancer cells subjected to estrogen starvation, GRP78 binds to the BCL2-interacting killer (BIK), a pro-apoptotic protein localized in the ER, inhibiting BIK’s and BAX’s apoptotic functions, implicating that targeting GRP78 may enhance the efficacy of hormonal therapy in breast cancer cells [84]. The gene discussed is BAX; the disease is breast carcinoma.