According to the behavior of cytokines after treatment, although there were no significant differences, it was observed that for most of them, especially IL-10 and IL-1β, the mean was below the cut-off point in all periodontal disease diagnoses, except for IL-17, IL-6, and IL-4 in stage III Grade A and stage IV Grade B periodontitis, which remained elevated. This evidence concerns the gene IL4 and periodontitis.