Looking more closely at the potential long-term cardiovascular benefits of periodontal therapy in hypertensive patients, it is important to mention Luo et al., who in a systematic review on the effect of periodontal treatments on blood pressure, report that randomized controlled trials (RCTs) have shown that periodontal treatment can significantly reduce plasma levels of systemic inflammatory markers (hs-CRP, IL-6, and fibrinogen) in people with hypertension and periodontitis. The gene discussed is IL6; the disease is Hypertension.