Regarding vascular endothelial growth factor (VEGF), which was reduced after periodontal treatment, Touyz et al. analyzed recent advances in hypertension and cardiovascular toxicity following VEGF inhibition, highlighting that inhibiting this biomarker is associated with a higher incidence of cardiovascular diseases, including hypertension, ischemic heart disease, heart failure, QT interval prolongation, and thromboembolism. The gene discussed is VEGFA; the disease is heart failure.