When analyzing the periodontal condition and cytokines after treatment in periodontally healthy patients and those with periodontitis, although no statistically significant differences were observed in these biomarkers, lower levels of inflammatory biomarkers such as IL-1β, IL-6, IL-8, IL-4, IL-12p70, and IL-17 were evident in patients who were periodontally healthy. This evidence concerns the gene CXCL8 and periodontitis.