TNF and Bartsocas-Papas syndrome 1: According to the results shown above, a diagnostic algorithm using a cluster of urinary biomarkers including TNF-α ≥ CQ3 or 8-OHDG ≥ CQ3 and 8-isoprastane ≥ CQ2 could identify patients with IC/BPS from the overall cohort, and adding the urinary IP-10 ≥ CQ2 or IP-10 ≥ CQ3 could detect HIC from the IC/BPS population (Figure 3).