The results of the secondary outcome analysis showed that increased troponin I AND BNP was associated with a significantly increased risk of IHD [HR 1.46 (1.26–1.69)], AMI [HR 1.53 (1.34–1.76)], HF [HR 1.66 (1.39–1.88)], atrial fibrillation and flutter [HR 1.37 (1.19–1.60)], and all-cause mortality [HR 1.52 (1.4–1.66)]. This evidence concerns the gene NPPB and myocardial ischemia.