The results of the secondary outcome analysis showed that increased BNP was associated with a significantly increased risk of IHD [HR 1.20 (1.04–1.39)], AMI [HR 1.26 (1.09–1.46)], HF [HR 1.41 (1.20–1.65)], atrial fibrillation and flutter [HR 1.29 (1.10–1.52)], and all-cause mortality [HR 1.40 (1.27–1.53)]. This evidence concerns the gene NPPB and atrial flutter.