Exosomal miR-320d from colorectal cancer cells promotes tumor spread and vascular growth by targeting G protein subunit alpha i1 (GNAI1) in ECs, triggering janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) activation and vascular endothelial growth factor A (VEGFA) production [104]. This evidence concerns the gene STAT3 and neoplasm.